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The THERAPET DERMAL line respects the hydro-lipid balance of the skin, thanks to the maintenance of the
physiological pH, the lipid component and the presence of natural active ingredients with soothing, moisturizing and
action
antioxidant.
The products of the THERAIDRA line are rich in emollient and moisturizing lipid substances, such as glycyrrhetinic acid, palmitoylethanolamide (PEA) and aloe vera, for cleansing the skin and coat even in the case of rashes or dermatitis in which it is necessary to restore the integrity of skin barrier and support the normal function of the skin microbiome. The key ingredient is BIOME21®, an original complex of ingredients (Acetyl Heptapeptide-4 and Inulin complex) capable of:
Strengthen the function of the skin barrier against physical agents and pathogens
Promote greater microbial diversity, balance of the skin microbiota and increase of beneficial bacteria on the skin
Increase the expression of genes associated with intercellular junctions, promoting the integrity of the skin barrier
Stimulating the immune response against keratinocyte pathogens
Modulate the profile of ceramides by promoting an increase in long-chain ceramides, essential for preserving the skin barrier
Significantly reduce the loss of water from the epidermis, preserving skin hydration.
In vitro efficacy studies have demonstrated the ability of BIOME21® to promote a change in the skin microbiota in favor of beneficial bacteria. Human keratinocytes were pre-incubated for 24 hours with BIOME21® or with a culture medium as a control. Subsequently, the epidermal cells were exposed to a mixture of green-fluorescent-labeled S.epidermidis and red-fluorescent inactivated S.aureus. The keratinocyte nuclei were stained with blue fluorescence.